Anti-Proliferative Actions of T-Type Calcium Channel Inhibition in Thy1 Nephritis

Aberrant proliferation of mesangial cells (MCs) is a key finding in progressive glomerular disease. TH1177 is a small molecule that has been shown to inhibit low-voltage activated T-type Ca(2+) channels (TCCs). The current study investigates the effect of TH1177 on MC proliferation in vitro and in v...

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Bibliographic Details
Main Authors: Cove-Smith, Andrea, Mulgrew, Christopher J., Rudyk, Olena, Dutt, Neelanjana, McLatchie, Linda M., Shattock, Michael J., Hendry, Bruce M.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2013
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730775/
https://ncbi.nlm.nih.gov/pubmed/23746655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.04.029
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