Rebmab200, a Humanized Monoclonal Antibody Targeting the Sodium Phosphate Transporter NaPi2b Displays Strong Immune Mediated Cytotoxicity against Cancer: A Novel Reagent for Targeted Antibody Therapy of Cancer

NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials but being murine the antibody's full therapeu...

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Główni autorzy: dos Santos, Mariana Lopes, Yeda, Fernanda Perez, Tsuruta, Lilian Rumi, Horta, Bruno Brasil, Pimenta, Alécio A., Degaki, Theri Leica, Soares, Ibere C., Tuma, Maria Carolina, Okamoto, Oswaldo Keith, Alves, Venancio A. F., Old, Lloyd J., Ritter, Gerd, Moro, Ana Maria
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729455/
https://ncbi.nlm.nih.gov/pubmed/23936189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070332
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