BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependen...

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Autors principals: Gorrini, Chiara, Baniasadi, Pegah S., Harris, Isaac S., Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A., Wakeham, Andrew, Molyneux, Sam D., Martin, Bernard, Bouwman, Peter, Cescon, David W., Elia, Andrew J., Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K., Khokha, Rama, Jonkers, Jos, Mak, Tak W., Gauthier, Mona L.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727320/
https://ncbi.nlm.nih.gov/pubmed/23857982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121337
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