Genetic Aberrations in Imatinib-Resistant Dermatofibrosarcoma Protuberans Revealed by Whole Genome Sequencing

Dermatofibrosarcoma protuberans (DFSP) is a very rare soft tissue sarcoma. DFSP often reveals a specific chromosome translocation, t(17;22)(q22;q13), which results in the fusion of collagen 1 alpha 1 (COL1A1) gene and platelet-derived growth factor-B (PDGFB) gene. The COL1A1-PDGFB fusion protein act...

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Autors principals: Hong, Jung Yong, Liu, Xiao, Mao, Mao, Li, Miao, Choi, Dong Il, Kang, Shin Woo, Lee, Jeeyun, La Choi, Yoon
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726773/
https://ncbi.nlm.nih.gov/pubmed/23922791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069752
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