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Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats

Memantine and ketamine block N-methyl-D-aspartate (NMDA) receptors with similar affinity and kinetics, yet their behavioral consequences differ: e.g., memantine is used to alleviate symptoms of Alzheimer’s disease, whereas ketamine reproduces symptoms of schizophrenia. The two drugs exhibit differen...

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Détails bibliographiques
Auteurs principaux: Kotermanski, Shawn E., Johnson, Jon W., Thiels, Edda
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723459/
https://ncbi.nlm.nih.gov/pubmed/23665480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2013.05.005
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