Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I

Caspase-12 has been shown to negatively modulate inflammasome signaling during bacterial infection. Its function in viral immunity, however, has not been characterized. We now report an important role for caspase-12 in controlling viral infection via the pattern-recognition receptor RIG-I. After cha...

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Autori principali: Wang, Penghua, Arjona, Alvaro, Zhang, Yue, Sultana, Hameeda, Dai, Jianfeng, Yang, Long, LeBlanc, Philippe M, Doiron, Karine, Saleh, Maya, Fikrig, Erol
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712356/
https://ncbi.nlm.nih.gov/pubmed/20818395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1933
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