Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions

OBJECTIVE: Clarithromycin strongly inhibits enzyme cytochrome P450 3A4, preventing the metabolism of some other drugs, while azithromycin is a weak inhibitor. Accordingly, blood concentrations of other drugs increase with clarithromycin coprescription leading to adverse events. These macrolide antib...

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Detalhes bibliográficos
Main Authors: Fleet, Jamie L, Shariff, Salimah Z, Bailey, David G, Gandhi, Sonja, Juurlink, David N, Nash, Danielle M, Mamdani, Muhammad, Gomes, Tara, Patel, Amit M, Garg, Amit X
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710981/
https://ncbi.nlm.nih.gov/pubmed/23847265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2013-002857
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