Reduced Sodium Transport With Nasal Administration of the Prostasin Inhibitor Camostat in Subjects With Cystic Fibrosis

BACKGROUND: Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport in cystic fibrosis (CF). METHODS: To d...

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Detalhes bibliográficos
Main Authors: Rowe, Steven M., Reeves, Ginger, Hathorne, Heather, Solomon, G. Martin, Abbi, Smita, Renard, Didier, Lock, Ruth, Zhou, Ping, Danahay, Henry, Clancy, John P., Waltz, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American College of Chest Physicians 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707174/
https://ncbi.nlm.nih.gov/pubmed/23412700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.12-2431
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