Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5

Aconitum, widely used to treat rheumatoid arthritis for thousands of years, is a toxic herb that can frequently cause fatal cardiac poisoning. Aconitum toxicity could be decreased by properly hydrolyzing diester-diterpene alkaloids into monoester-diterpene alkaloids. Monoester-diterpene alkaloids, i...

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Autores principales: Ye, Ling, Yang, Xiao-Shan, Lu, Lin-lin, Chen, Wei-Ying, Zeng, Shan, Yan, Tong-Meng, Dong, Ling-Na, Peng, Xiao-Juan, Shi, Jian, Liu, Zhong-Qiu
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705941/
https://ncbi.nlm.nih.gov/pubmed/23864901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/941093
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