ALDH2 protects against stroke by clearing 4-HNE

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 deficiency in stroke-prone spontaneously hypertensive rats (SHR-SP) as compared with spontaneously hype...

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Autores principales: Guo, Jin-Min, Liu, Ai-Jun, Zang, Pu, Dong, Wen-Zhe, Ying, Li, Wang, Wei, Xu, Pu, Song, Xu-Rui, Cai, Jun, Zhang, She-Qing, Duan, Jun-Li, Mehta, Jawahar L, Su, Ding-Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698638/
https://ncbi.nlm.nih.gov/pubmed/23689279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.69
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