Understanding the Molecular Determinants Driving the Immunological Specificity of the Protective Pilus 2a Backbone Protein of Group B Streptococcus

The pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main immunologically distinct allelic variants, each inducing variant-specific protection. To i...

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Main Authors: Nuccitelli, Annalisa, Rinaudo, C. Daniela, Brogioni, Barbara, Cozzi, Roberta, Ferrer-Navarro, Mario, Yero, Daniel, Telford, John L., Grandi, Guido, Daura, Xavier, Zacharias, Martin, Maione, Domenico
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694817/
https://ncbi.nlm.nih.gov/pubmed/23825940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003115
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