A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone–Collagen Binding Domain (PTH–CBD), Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female Mice

Parathyroid hormone (PTH) is the most effective osteoporosis treatment, but it is only effective if administered by daily injections. We fused PTH(1–33) to a collagen binding domain (PTH–CBD) to extend its activity, and have shown an anabolic bone effect with monthly dosing. We tested the duration o...

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Bibliografische gegevens
Hoofdauteurs: Ponnapakkam, Tulasi, Katikaneni, Ranjitha, Suda, Hirofumi, Miyata, Shigeru, Matsushita, Osamu, Sakon, Joshua, Gensure, Robert C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693552/
https://ncbi.nlm.nih.gov/pubmed/22806683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-012-9626-1
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