Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor α (sIL-15Rα). Here, we show efficient p...

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Bibliographische Detailangaben
Hauptverfasser: Chertova, Elena, Bergamaschi, Cristina, Chertov, Oleg, Sowder, Raymond, Bear, Jenifer, Roser, James D., Beach, Rachel K., Lifson, Jeffrey D., Felber, Barbara K., Pavlakis, George N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689953/
https://ncbi.nlm.nih.gov/pubmed/23649624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461756
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