PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat

A PPARγ fluorescence polarization (FP) assay was used to measure the release of fatty acid products from triglyceride emulsions during digestion with pancreatic and yeast lipases in a real-time, homogenous assay. Using the same FP assay we show the anti-obesity drug Orlistat is a PPARγ ligand with a...

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Main Authors: Martin, Harry, McGhie, Tony K, Bentley-Hewitt, Kerry, Christeller, John
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681555/
https://ncbi.nlm.nih.gov/pubmed/23566279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-12-48
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