Selective inhibition of vagal afferent nerve pathways regulating cough using Na(v) 1.7 shRNA silencing in guinea pig nodose ganglia

Adeno-associated virus delivery systems and short hairpin RNA (shRNA) were used to selectively silence the voltage-gated sodium channel Na(V) 1.7 in the nodose ganglia of guinea pigs. The cough reflex in these animals was subsequently assessed. Na(V) 1.7 shRNA was delivered to the majority of nodose...

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Main Authors: Muroi, Yukiko, Ru, Fei, Chou, Yang-Ling, Carr, Michael J., Undem, Bradley J., Canning, Brendan J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2013
Ábhair:
Neural Control
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680757/
https://ncbi.nlm.nih.gov/pubmed/23576611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00028.2013
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