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Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis
JAK-STAT is a rational drug target in myelofibrosis (MF) given its association with JAK2/MPL mutations and aberrant inflammatory cytokine expression. We conducted a Phase 1/2 trial of CYT387, a potent JAK1/2 inhibitor, in patients with high- or intermediate-risk primary or post-polycythemia vera/ess...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Nature Publishing Group
2013
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677140/ https://ncbi.nlm.nih.gov/pubmed/23459451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.71 |
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