The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin

Interindividual variation in response to metformin, first-line therapy for type 2 diabetes, is substantial. Given that transporters are determinants of metformin pharmacokinetics, we examined the effects of promoter variants in both multidrug and toxin extrusion protein 1 (MATE1) (g.−66T→C, rs225228...

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Hauptverfasser: Stocker, Sophie L., Morrissey, Kari M., Yee, Sook Wah, Castro, Richard A., Xu, Lu, Dahlin, Amber, Ramirez, Andrea H., Roden, Dan M., Wilke, Russ A., McCarty, Cathy A., Davis, Robert L., Brett, Claire M., Giacomini, Kathleen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671611/
https://ncbi.nlm.nih.gov/pubmed/23267855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.210
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