Nitric Oxide Modifies Global Histone Methylation by Inhibiting Jumonji C Domain-containing Demethylases

Methylation of lysine residues on histone tails is an important epigenetic modification that is dynamically regulated through the combined effects of methyltransferases and demethylases. The Jumonji C domain Fe(II) α-ketoglutarate family of proteins performs the majority of histone demethylation. We...

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Bibliographic Details
Main Authors: Hickok, Jason R., Vasudevan, Divya, Antholine, William E., Thomas, Douglas D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668755/
https://ncbi.nlm.nih.gov/pubmed/23546878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432294
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