TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive malignancy closely associated with asbestos exposure and extremely resistant to current treatments. It exhibits a steady increase in incidence, thus necessitating an urgent development of effective new treatments. METHODS: Proteasome...

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Hauptverfasser: Yuan, Bao-Zhu, Chapman, Joshua, Ding, Min, Wang, Junzhi, Jiang, Binghua, Rojanasakul, Yon, Reynolds, Steven H
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665596/
https://ncbi.nlm.nih.gov/pubmed/23517112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-140
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