Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer

In this study, we hypothesized that androgen-deprivation therapy (ADT) in prostate cancer, although initially efficient, induces changes in the tumor kinome, which subsequently promote development of castration-resistant (CR) disease. Recognizing the correlation between tumor hypoxia and poor progno...

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Hauptverfasser: Røe, Kathrine, Bratland, Åse, Vlatkovic, Ljiljana, Ragnum, Harald Bull, Saelen, Marie Grøn, Olsen, Dag Rune, Marignol, Laure, Ree, Anne Hansen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651196/
https://ncbi.nlm.nih.gov/pubmed/23675504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063723
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