The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic DNA. The newly generated DNA end is subsequently used as a primer to initiate reverse transcription within the L1 RNA p...

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Detalhes bibliográficos
Main Authors: Monot, Clément, Kuciak, Monika, Viollet, Sébastien, Mir, Ashfaq Ali, Gabus, Caroline, Darlix, Jean-Luc, Cristofari, Gaël
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649969/
https://ncbi.nlm.nih.gov/pubmed/23675310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003499
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