Enhanced Prostacyclin Synthesis by Adenoviral Gene Transfer Reduced Glial Activation and Ameliorated Dopaminergic Dysfunction in Hemiparkinsonian Rats

Prostacyclin (PGI(2)), a potent vasodilator and platelet antiaggregatory eicosanoid, is cytoprotective in cerebral circulation. It is synthesized from arachidonic acid (AA) by the sequential action of cyclooxygenase- (COX-) 1 or 2 and prostacyclin synthase (PGIS). Because prostacyclin is unstable in...

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Hlavní autoři: Tsai, May-Jywan, Weng, Ching-Feng, Yu, Nien-Chu, Liou, Dann-Ying, Kuo, Fu-San, Huang, Ming-Chao, Huang, Wen-Cheng, Tam, Kabik, Shyue, Song-Kun, Cheng, Henrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649752/
https://ncbi.nlm.nih.gov/pubmed/23691265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/649809
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