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UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts
Mitochondrial DNA (mtDNA) is more susceptible than nuclear DNA to helix-distorting damage via exposure to environmental genotoxins, partially due to a lack of nucleotide excision repair (NER). Thus, this damage is irreparable and persistent in mtDNA in the short term. We recently found that helix-di...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640456/ https://ncbi.nlm.nih.gov/pubmed/23132756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbt.21440 |
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