Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure

Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N...

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Bibliografiska uppgifter
Huvudupphovsmän: Huang, Stephen S. H., Lin, Zhen, Banner, David, León, Alberto J., Paquette, Stéphane G., Rubin, Barry, Rubino, Salvatore, Guan, Yi, Kelvin, David J., Kelvin, Alyson A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633051/
https://ncbi.nlm.nih.gov/pubmed/23608887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01698
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