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Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility
The expression of Na(+)–K(+)–2Cl(−) cotransporter (NKCC1) is responsible for high intracellular Cl(−) resulting in the excitatory action of GABA(A) receptor activation in the developing brain. Giant depolarizing potentials (GDPs) are spontaneous network oscillations that involve GABA(A) receptors an...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630771/ https://ncbi.nlm.nih.gov/pubmed/23006485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.234674 |
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