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Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy

A detailed account of the enantioselective total synthesis of (-)-zampanolide, a macrolide marine natural product with high anti-cancer activity is described. For synthesis of the 4-methylene tetrahydropyran unit of (-)-zampanolide, initially, we relied upon an oxidative C-H activation of an alkenyl...

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Autors principals: Ghosh, Arun K., Cheng, Xu, Bai, Ruoli, Hamel, Ernest
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629982/
https://ncbi.nlm.nih.gov/pubmed/23606808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201200286
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