The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes

HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy (Neuro-cART) regimens, but their relative activit...

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Bibliographic Details
Main Authors: Gray, Lachlan R., Tachedjian, Gilda, Ellett, Anne M., Roche, Michael J., Cheng, Wan-Jung, Guillemin, Gilles J., Brew, Bruce J., Turville, Stuart G., Wesselingh, Steve L., Gorry, Paul R., Churchill, Melissa J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628669/
https://ncbi.nlm.nih.gov/pubmed/23614033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062196
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