Activation of a Non-cAMP/PKA Signaling Pathway Downstream of the PTH/PTHrP Receptor Is Essential for a Sustained Hypophosphatemic Response to PTH Infusion in Male Mice

PTH increases urinary Pi excretion by reducing expression of two renal cotransporters [NaPi-IIa (Npt2a) and NaPi-IIc (Npt2c)]. In contrast to acute transporter regulation that is cAMP/protein kinase A dependent, long-term effects require phospholipase C (PLC) signaling by the PTH/PTHrP receptor (PPR...

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Detalhes bibliográficos
Main Authors: Guo, Jun, Song, Lige, Liu, Minlin, Segawa, Hiroko, Miyamoto, Ken-Ichi, Bringhurst, F. Richard, Kronenberg, Henry M., Jüppner, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Calcium-Regulating Hormones
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628020/
https://ncbi.nlm.nih.gov/pubmed/23515284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2240
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