The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*

OBJECTIVES: Plasma tryptophan levels are associated with delirium in critically ill patients. Although tryptophan has been linked to the pathogenesis of other neurocognitive diseases through metabolism to neurotoxins via the kynurenine pathway, a role for kynurenine pathway activity in intensive car...

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Hlavní autoři: Adams Wilson, Jessica R., Morandi, Alessandro, Girard, Timothy D., Thompson, Jennifer L., Boomershine, Chad S., Shintani, Ayumi K., Ely, E. Wesley, Pandharipande, Pratik P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625666/
https://ncbi.nlm.nih.gov/pubmed/22080637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318236f62d
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