1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

The 1918 pandemic influenza virus was the most devastating infectious agent in human history, causing fatal pneumonia and an estimated 20 to 50 million deaths worldwide. Previous studies indicated a prominent role of the hemagglutinin (HA) gene in efficient replication and high virulence of the 1918...

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Bibliografiske detaljer
Main Authors: Watanabe, Tokiko, Tisoncik-Go, Jennifer, Tchitchek, Nicolas, Watanabe, Shinji, Benecke, Arndt G., Katze, Michael G., Kawaoka, Yoshihiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624330/
https://ncbi.nlm.nih.gov/pubmed/23449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02753-12
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