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DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase
Substrate engagement by F-box proteins promotes NEDD8 modification of cullins, which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). However, the mechanism by which substrate recruitment triggers cullin neddylation remains unclear. Here, we identify DCNL1 (defective in cu...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624248/ https://ncbi.nlm.nih.gov/pubmed/23401859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01342-12 |
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