Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period

Cardiomyocytes proliferate during fetal life but lose their ability to proliferate soon after birth and further increases in cardiac mass are achieved through an increase in cell size or hypertrophy. Mammalian target of rapamycin complex 1 (mTORC1) is critical for cell growth and proliferation. Rheb...

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Hauptverfasser: Tamai, Takahito, Yamaguchi, Osamu, Hikoso, Shungo, Takeda, Toshihiro, Taneike, Manabu, Oka, Takafumi, Oyabu, Jota, Murakawa, Tomokazu, Nakayama, Hiroyuki, Uno, Yoshihiro, Horie, Kyoji, Nishida, Kazuhiko, Sonenberg, Nahum, Shah, Ajay M., Takeda, Junji, Komuro, Issei, Otsu, Kinya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617260/
https://ncbi.nlm.nih.gov/pubmed/23426372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423640
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