Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period

Cardiomyocytes proliferate during fetal life but lose their ability to proliferate soon after birth and further increases in cardiac mass are achieved through an increase in cell size or hypertrophy. Mammalian target of rapamycin complex 1 (mTORC1) is critical for cell growth and proliferation. Rheb...

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Detalhes bibliográficos
Main Authors: Tamai, Takahito, Yamaguchi, Osamu, Hikoso, Shungo, Takeda, Toshihiro, Taneike, Manabu, Oka, Takafumi, Oyabu, Jota, Murakawa, Tomokazu, Nakayama, Hiroyuki, Uno, Yoshihiro, Horie, Kyoji, Nishida, Kazuhiko, Sonenberg, Nahum, Shah, Ajay M., Takeda, Junji, Komuro, Issei, Otsu, Kinya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617260/
https://ncbi.nlm.nih.gov/pubmed/23426372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423640
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