Cysteine (C)-X-C Receptor 4 Undergoes Transportin 1-Dependent Nuclear Localization and Remains Functional at the Nucleus of Metastatic Prostate Cancer Cells

The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that support transformation, progression and eventual metastasis. Due to the central...

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Main Authors: Don-Salu-Hewage, Ayesha S., Chan, Siu Yuen, McAndrews, Kathleen M., Chetram, Mahandranauth A., Dawson, Michelle R., Bethea, Danaya A., Hinton, Cimona V.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585330/
https://ncbi.nlm.nih.gov/pubmed/23468933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057194
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