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Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression

Cancer progression is a complex series of events thought to incorporate the reversible developmental process of epithelial-to-mesenchymal transition (EMT). In vitro, the microRNA-200 family maintains the epithelial phenotype by posttranscriptionally inhibiting the E-cadherin repressors, ZEB1 and ZEB...

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Autori principali: Paterson, Emily L, Kazenwadel, Jan, Bert, Andrew G, Khew-Goodall, Yeesim, Ruszkiewicz, Andrew, Goodall, Gregory J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579320/
https://ncbi.nlm.nih.gov/pubmed/23441132
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