Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

[Image: see text] Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter ra...

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Bibliographic Details
Main Authors: Cui, Liang, Ye, Wenjie, Prestwich, Erin G., Wishnok, John S., Taghizadeh, Koli, Dedon, Peter C., Tannenbaum, Steven R.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578445/
https://ncbi.nlm.nih.gov/pubmed/23140136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300294d
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