Tra2-Mediated Recognition of HIV-1 5′ Splice Site D3 as a Key Factor in the Processing of vpr mRNA

Small noncoding HIV-1 leader exon 3 is defined by its splice sites A2 and D3. While 3′ splice site (3′ss) A2 needs to be activated for vpr mRNA formation, the location of the vpr start codon within downstream intron 3 requires silencing of splicing at 5′ss D3. Here we show that the inclusion of both...

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Autori principali: Erkelenz, Steffen, Poschmann, Gereon, Theiss, Stephan, Stefanski, Anja, Hillebrand, Frank, Otte, Marianne, Stühler, Kai, Schaal, Heiner
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571381/
https://ncbi.nlm.nih.gov/pubmed/23255807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02756-12
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