Tra2-Mediated Recognition of HIV-1 5′ Splice Site D3 as a Key Factor in the Processing of vpr mRNA

Small noncoding HIV-1 leader exon 3 is defined by its splice sites A2 and D3. While 3′ splice site (3′ss) A2 needs to be activated for vpr mRNA formation, the location of the vpr start codon within downstream intron 3 requires silencing of splicing at 5′ss D3. Here we show that the inclusion of both...

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Bibliographic Details
Main Authors: Erkelenz, Steffen, Poschmann, Gereon, Theiss, Stephan, Stefanski, Anja, Hillebrand, Frank, Otte, Marianne, Stühler, Kai, Schaal, Heiner
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571381/
https://ncbi.nlm.nih.gov/pubmed/23255807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02756-12
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