Tra2-Mediated Recognition of HIV-1 5′ Splice Site D3 as a Key Factor in the Processing of vpr mRNA

Small noncoding HIV-1 leader exon 3 is defined by its splice sites A2 and D3. While 3′ splice site (3′ss) A2 needs to be activated for vpr mRNA formation, the location of the vpr start codon within downstream intron 3 requires silencing of splicing at 5′ss D3. Here we show that the inclusion of both...

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Autors principals: Erkelenz, Steffen, Poschmann, Gereon, Theiss, Stephan, Stefanski, Anja, Hillebrand, Frank, Otte, Marianne, Stühler, Kai, Schaal, Heiner
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571381/
https://ncbi.nlm.nih.gov/pubmed/23255807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02756-12
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