C-Terminal trans-activation sub-region of VP16 is uniquely required for forskolin-induced herpes simplex virus type 1 reactivation from quiescently infected-PC12 cells but not for replication in neuronally differentiated-PC12 cells

The HSV-1 tegument protein VP16 contains a trans-activation domain (TAD) that is required for induction of immediate early (IE) genes during lytic infection and induced reactivation from latency. Here we report the differential contributions of the two sub-regions of the TAD in neuronal and non-neur...

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Bibliographic Details
Main Authors: Danaher, Robert J., Cook, Ross K., Wang, Chunmei, Triezenberg, Steven J., Jacob, Robert J., Miller, Craig S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568243/
https://ncbi.nlm.nih.gov/pubmed/23192733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-012-0137-7
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