Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

Methyltransferases use S-adenosylmethionine (AdoMet) as methyl group donor, forming S-adenosylhomocysteine (AdoHcy) and methylated substrates, including DNA and proteins. AdoHcy inhibits most methyltransferases. Accumulation of intracellular AdoHcy secondary to Hcy elevation elicits global DNA hypom...

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Main Authors: Esse, Ruben, Rocha, Monica S., Barroso, Madalena, Florindo, Cristina, Teerlink, Tom, Kok, Robert M., Smulders, Yvo M., Rivera, Isabel, Leandro, Paula, Koolwijk, Pieter, Castro, Rita, Blom, Henk J., de Almeida, Isabel Tavares
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568140/
https://ncbi.nlm.nih.gov/pubmed/23408989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055483
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