High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat C(H) Region

Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional mice yield mouse mAbs. Suboptimal efficacy in delivery of human Abs might reflect imperfect interaction between the human memb...

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Detalhes bibliográficos
Main Authors: Osborn, Michael J., Ma, Biao, Avis, Suzanne, Binnie, Ashleigh, Dilley, Jeanette, Yang, Xi, Lindquist, Kevin, Ménoret, Séverine, Iscache, Anne-Laure, Ouisse, Laure-Hélène, Rajpal, Arvind, Anegon, Ignacio, Neuberger, Michael S., Buelow, Roland, Brüggemann, Marianne
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2013
Assuntos:
Clinical and Human Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566577/
https://ncbi.nlm.nih.gov/pubmed/23303672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203041
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