High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat C(H) Region

Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional mice yield mouse mAbs. Suboptimal efficacy in delivery of human Abs might reflect imperfect interaction between the human memb...

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Bibliografische gegevens
Hoofdauteurs: Osborn, Michael J., Ma, Biao, Avis, Suzanne, Binnie, Ashleigh, Dilley, Jeanette, Yang, Xi, Lindquist, Kevin, Ménoret, Séverine, Iscache, Anne-Laure, Ouisse, Laure-Hélène, Rajpal, Arvind, Anegon, Ignacio, Neuberger, Michael S., Buelow, Roland, Brüggemann, Marianne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AAI 2013
Onderwerpen:
Clinical and Human Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566577/
https://ncbi.nlm.nih.gov/pubmed/23303672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203041
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