High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Igκ/Igλ Loci Bearing the Rat C(H) Region

Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional mice yield mouse mAbs. Suboptimal efficacy in delivery of human Abs might reflect imperfect interaction between the human memb...

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Main Authors: Osborn, Michael J., Ma, Biao, Avis, Suzanne, Binnie, Ashleigh, Dilley, Jeanette, Yang, Xi, Lindquist, Kevin, Ménoret, Séverine, Iscache, Anne-Laure, Ouisse, Laure-Hélène, Rajpal, Arvind, Anegon, Ignacio, Neuberger, Michael S., Buelow, Roland, Brüggemann, Marianne
格式: Artigo
語言:Inglês
出版: AAI 2013
主題:
Clinical and Human Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566577/
https://ncbi.nlm.nih.gov/pubmed/23303672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203041
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