Mannose 6-Phosphate Conjugation Is Not Sufficient to Allow Induction of Immune Tolerance to Phenylalanine Ammonia-Lyase in Dogs

The immune response to exogenous protein has been shown to reduce therapeutic efficacy in animal models of enzyme replacement therapy. A previously published study demonstrated an immunosuppressive regimen which successfully induced immune tolerance to α-l-iduronidase in canines with mucopolysacchar...

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Detalhes bibliográficos
Main Authors: Vera, Moin, Lester, Thomas, Zhao, Bin, Tiger, Pascale, Clarke, Scott, Tippin, Brigette L., Passage, Merry B., Le, Steven Q., Femenia, Javier, Lemontt, Jeffrey F., Kakkis, Emil D., Dickson, Patricia I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565636/
https://ncbi.nlm.nih.gov/pubmed/23430522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/8904_2012_162
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