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Correction of the ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Gene by Zinc-Finger Nuclease Homology-Directed Repair

The use of zinc-finger nucleases (ZFNs) to permanently and precisely modify the human genome offers a potential alternative to cDNA-based gene therapy. The ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is observed in ∼70% of patients with cystic fibrosis (CF)...

詳細記述

保存先:
書誌詳細
主要な著者: Lee, Ciaran M., Flynn, Rowan, Hollywood, Jennifer A., Scallan, Martina F., Harrison, Patrick T.
フォーマット: Artigo
言語:Inglês
出版事項: Mary Ann Liebert, Inc. 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559198/
https://ncbi.nlm.nih.gov/pubmed/23514673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/biores.2012.0218
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