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Statistical analysis of SHAPE-directed RNA secondary structure modeling

The ability to predict RNA secondary structure is fundamental for understanding and manipulating RNA function. The structural information obtained from selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) experiments greatly improves the accuracy of RNA secondary structure predi...

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Bibliographic Details
Main Authors: Ramachandran, Srinivas, Ding, Feng, Weeks, Kevin M., Dokholyan, Nikolay V.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558531/
https://ncbi.nlm.nih.gov/pubmed/23286327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300756s
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