Ribavirin-Resistant Mutants of Human Enterovirus 71 Express a High Replication Fidelity Phenotype during Growth in Cell Culture

It has been shown in animal models that ribavirin-resistant poliovirus with a G64S mutation in its 3D polymerase has high replication fidelity coupled with attenuated virulence. Here, we describe the effects of mutagenesis in the human enterovirus 71 (HEV71) 3D polymerase on ribavirin resistance and...

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Bibliografiske detaljer
Main Authors: Sadeghipour, Sara, Bek, Emily J., McMinn, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554166/
https://ncbi.nlm.nih.gov/pubmed/23175376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02139-12
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