Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission

Rifampin resistance in clinical isolates of Mycobacterium tuberculosis arises primarily through the selection of bacterial variants harboring mutations in the 81-bp rifampin resistance-determining region of the rpoB gene. While these mutations were shown to infer a fitness cost in the absence of ant...

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Bibliographische Detailangaben
Hauptverfasser: de Vos, M., Müller, B., Borrell, S., Black, P. A., van Helden, P. D., Warren, R. M., Gagneux, S., Victor, T. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553702/
https://ncbi.nlm.nih.gov/pubmed/23208709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01541-12
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