Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

Activation of mitosis promoting factor (MPF) drives mitotic commitment(1). In human cells active MPF appears first on centrosomes(2). We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo kinase activity at the SPBs long before...

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Päätekijät: Grallert, Agnes, Patel, Avinash, Tallada, Victor A., Chan, Kuan Yoow, Bagley, Steven, Krapp, Andrea, Simanis, Viesturs, Hagan, Iain M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549529/
https://ncbi.nlm.nih.gov/pubmed/23222840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2633
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