Cardiac PI3K-Akt Impairs Insulin-Stimulated Glucose Uptake Independent of mTORC1 and GLUT4 Translocation

Impaired insulin-mediated glucose uptake characterizes cardiac muscle in humans and animals with insulin resistance and diabetes, despite preserved or enhanced phosphatidylinositol 3-kinase (PI3K) and the serine-threonine kinase, Akt-signaling, via mechanisms that are incompletely understood. One po...

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Autori principali: Zhu, Yi, Pereira, Renata O., O'Neill, Brian T, Riehle, Christian, Ilkun, Olesya, Wende, Adam R., Rawlings, Tenley A., Zhang, Yi Cheng, Zhang, Quanjiang, Klip, Amira, Shiojima, Ichiro, Walsh, Kenneth, Abel, E. Dale
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545208/
https://ncbi.nlm.nih.gov/pubmed/23204326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1210
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